Anti-Slow skeletal Myosin antibody (ab98835)

Overview

  • Product nameAnti-Slow skeletal Myosin antibodySee all Slow skeletal Myosin primary antibodies ...
  • Description
    Rabbit polyclonal to Slow skeletal Myosin
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Saccharomyces cerevisiae
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35 - 84 (VEFDASKIKI EFTPEQIEEF KEAFMLFDRT PKCEMKITYG QCGDVLRALG) of Human Slow skeletal Myosin (NP_000249).

  • Positive control
    • COLO205 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab98835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionRegulatory light chain of myosin. Does not bind calcium.
  • Involvement in diseaseDefects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
    Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
  • Sequence similaritiesContains 3 EF-hand domains.
  • Post-translational
    modifications
    The N-terminus is blocked.
    N-terminus is methylated by METTL11A/NTM1.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cardiac myosin light chain 1 antibody
    • CMH8 antibody
    • CMLC1 antibody
    • MLC1SB antibody
    • MLC1V antibody
    • MYL3 antibody
    • MYL3_HUMAN antibody
    • Myosin light chain 1 antibody
    • Myosin light chain 1 slow twitch muscle B ventricular isoform antibody
    • myosin light chain 3 alkali ventricular skeletal slow antibody
    • Myosin light chain 3 antibody
    • slow-twitch muscle B/ventricular isoform antibody
    • Ventricular slow twitch myosin alkali light chain antibody
    • Ventricular/slow twitch myosin alkali light chain antibody
    • VLC1 antibody
    see all

Anti-Slow skeletal Myosin antibody images

  • Anti-Slow skeletal Myosin antibody (ab98835) at 1 µg/ml + COLO205 cell lysate at 10 µg

    Predicted band size : 22 kDa

References for Anti-Slow skeletal Myosin antibody (ab98835)

ab98835 has not yet been referenced specifically in any publications.

Product Wall

Thank you so much for sending these images. They will be very helpful, and I am sending them on to the lab for review.

I am also sending a free of charge vial of ab91506 on the order ***, which should arrive tomorrow. Please keep me updated a...

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Thanks for your call today and for letting us know about this problem. We really appreciate your feedback, and I will forward any data that you can send to the lab for their review.

As we discussed, I'm happy to send a replacement antibody fo...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"