Anti-Slow skeletal Myosin antibody (ab98835)

Overview

• Product nameAnti-Slow skeletal Myosin antibodySee all Slow skeletal Myosin primary antibodies ...
• Description
  Rabbit polyclonal to Slow skeletal Myosin
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic peptide corresponding to a region within N terminal amino acids 35 - 84 (VEFDASKIKI EFTPEQIEEF KEAFMLFDRT PKCEMKITYG QCGDVLRALG) of Human Slow skeletal Myosin (NP_000249).

  Run BLAST with Run BLAST with
• Positive controlCOLO205 cell lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Developmental Biology
  • Lineage specification
  • Mesoderm

  • Stem Cells
  • Lineage Markers
  • Mesoderm

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Motor Proteins
  • Myosin

Applications

Target

• FunctionRegulatory light chain of myosin. Does not bind calcium.
• Involvement in diseaseDefects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
  Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
• Sequence similaritiesContains 3 EF-hand domains.
• Post-translational
  modificationsThe N-terminus is blocked.
  N-terminus is methylated by METTL11A/NTM1.

Target information above from: UniProt accession P08590 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 4634 Human
  • Entrez Gene: 17897 Mouse
  • Entrez Gene: 24585 Rat
  • Omim: 160790 Human
  • SwissProt: P08590 Human
  • SwissProt: P09542 Mouse
  • SwissProt: P16409 Rat
  • Unigene: 517939 Human

  • Unigene: 7353 Mouse
  • Unigene: 1955 Rat

  see all

• Alternative names
  Cardiac myosin light chain 1 antibodyCMH8 antibodyCMLC1 antibody

  MLC1SB antibodyMLC1V antibodyMYL3 antibodyMYL3_HUMAN antibodyMyosin light chain 1 antibodyMyosin light chain 1 slow twitch muscle B ventricular isoform antibodymyosin light chain 3 alkali ventricular skeletal slow antibodyMyosin light chain 3 antibodyslow-twitch muscle B/ventricular isoform antibodyVentricular slow twitch myosin alkali light chain antibodyVentricular/slow twitch myosin alkali light chain antibodyVLC1 antibody

  see all

Anti-Slow skeletal Myosin antibody images

• 

  Western blot - Slow skeletal Myosin antibody (ab98835)
  Anti-Slow skeletal Myosin antibody (ab98835) at 1 µg/ml + COLO205 cell lysate at 10 µg
  
  Predicted band size : 22 kDa