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MitoSciences (MS719)

Anti-Smac / Diablo antibody [8H5AB2] (ab110291)

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Overview

  • Product nameAnti-Smac / Diablo antibody [8H5AB2]See all Smac / Diablo primary antibodies ...
  • Description
    Mouse monoclonal [8H5AB2] to Smac / Diablo
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant Smac, TIMM22 proteins

  • Positive controlHuman liver mitochondria and HepG2 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab110291 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa.

Target

  • FunctionPromotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).
  • Tissue specificityUbiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.
  • DomainThe mature N-terminus mediates interaction with XIAP.
  • Cellular localizationMitochondrion. Released into the cytosol when cells undergo apoptosis.

    • Target information above from: UniProt accession Q9NR28 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        0610041G12Rik antibodyDBLOH_HUMAN antibodyDBOH antibody
        diablo antibodyDiablo homolog (Drosophila) antibodyDiablo homolog antibodyDiablo homolog mitochondrial antibodyDIABLO S antibodyDirect IAP binding protein with low pI antibodyDirect IAP-binding protein with low pI antibodyFLJ10537 antibodyFLJ25049 antibodymitochondrial antibodyMitochondrial Smac protein antibodySecond mitochondria derived activator of caspase antibodySecond mitochondria-derived activator of caspase antibodySMAC 3 antibodySmac antibodySmac protein antibodySMAC3 antibody
      see all

    Anti-Smac / Diablo antibody [8H5AB2] images

    • Western blot - Smac / Diablo antibody [8H5AB2] (ab110291)
      Western blot - Smac / Diablo antibody [8H5AB2] (ab110291)
      All lanes : Anti-Smac / Diablo antibody [8H5AB2] (ab110291) at 1 µg/ml

      Lane 1 : Human liver mitichondria
      Lane 2 : HepG2 cells


      Predicted band size : 27 kDa

    References for Anti-Smac / Diablo antibody [8H5AB2] (ab110291)

    ab110291 has not yet been referenced specifically in any publications.

    Publishing research using ab110291 ? Please let us know so that we can cite the reference in this datasheet

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    thank you very much for information regarding ab110291 antibody, lot#1113957 to Smac/Diablo. I really had some trouble with this batch of antibody, it doesn't work. So I would like to accept a compensation via free of charge vial from a different...

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    Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products. I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. A...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"