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Smac / Diablo peptide (ab8380)

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Overview

Product name

Smac / Diablo peptide
See all Smac / Diablo products (7) ...

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS with 0.1% BSA 0.02% sodium azide pH7.2

Concentration

Concentration information loading...

Sequence notes

EERAESEQEAYLRED Amino acids 225 to 239 of human Smac/DIABLO (1)

Research areas

Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> IAPs
Cell Biology >> Apoptosis >> Mitochondrial
Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs
Cell Biology >> Apoptosis >> Receptors >> Death Receptors

Applications

Show applications key

Our Abpromise guarantee covers the use of ab8380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Blocking

     

Application notes

The peptide is used for blocking the antibody activity of ab8114. It usually blocks the antibody activity completely in Western blot by incubating the peptidewith equal volume of antibody for 30 min at 37°C

Protein info

Function

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).

Tissue specificity

Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.

Domain

The mature N-terminus mediates interaction with XIAP.

Cellular localization

Mitochondrion. Released into the cytosol when cells undergo apoptosis.

Target information above from: UniProt accessionQ9NR28 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for Smac / Diablo peptide (ab8380)

ab8380 has not yet been referenced specifically in any publications.

Publishing research using ab8380? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"