Anti-Soluble TNF Receptor I antibody (ab34842)

Overview

• Product nameAnti-Soluble TNF Receptor I antibodySee all Soluble TNF Receptor I primary antibodies ...
• Description
  Rabbit polyclonal to Soluble TNF Receptor I
• SpecificityIn ELISA formats and other immunoreactive assays, ab34842 will detect the extracellular domain of the TNF receptor p55 found in human body fluids, particularly in the circulation, urine and supernatants of cells and synovial fluid. ab34842 does not recognize human Soluble TNF receptor p75.
• Tested applicationsIP, ELISA, RIA, WB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Non Human Primates
• Immunogen

  Recombinant full length protein (Human) expressed in Chinese Hamster Cells

• Epitopeab34843 is directed against the extracellular domain of the cell bound human TNF receptor p55.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.01% Sodium Azide
  Constituents: Whole serum
• PurityWhole antiserum
• Purification notesThis antiserum has been sterile filtered and heated to 56°C for 30 minutes.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • NFkB Pathway

  • Signal Transduction
  • Growth Factors/Hormones
  • TNF

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Polymerase associated factors
  • Pol II Transcription
  • Other

  • Immunology
  • Innate Immunity
  • Cytokines
  • Necrosis Factors

  • Cell Biology
  • Apoptosis
  • Receptors
  • Death Receptors

Applications

Target

• RelevanceTNF RI (CD120a) is a 55 kDa transmembrane glycoprotein that is expressed by virtually all nucleated mammalian cells. Among the numerous cells known to express TNF RI are hepatocytes, monocytes and neutrophils, cardiac muscle cells, endothelial cells, and CD34+ hematopoietic progenitors. Both TNF alpha and TNF beta bind to TNF RI. Soluble TNF alpha binds with a Kda in the range of 20-60 pM, while TNF beta binds with a Kda equal to 650 pM. TNF RI relative to TNF RII seems to be the more physiologically relevant receptor, whereas TNF R2 appears to play a direct role in only a limited number of TNF responses. Soluble TNF RI, which blocks TNF alpha activity, has been identified in both urine and blood (1-3 ng/mL). Serum levels of sTNF receptors increase dramatically in certain pathological situations.
• Cellular localizationCytoplasmic
• Database links
  • Entrez Gene: 7132 Human
  • Omim: 191190 Human
  • SwissProt: P19438 Human

• Alternative names
  CD120a antibodyp55 antibodyp60 antibody

  Soluble TNF p55 Receptor antibodySoluble TNFR p55 antibodyTBP1 antibodyTNF R1 antibodyTNFR I antibodyTNFR1 antibodyTNFR55 antibodyTNFRSF1A antibodyTumor necrosis factor alpha receptor antibodyTumor necrosis factor binding protein 1 antibodyTumor necrosis factor receptor 1 antibody

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