Overview
- Product nameAnti-Soluble TNF Receptor II antibodySee all Soluble TNF Receptor II primary antibodies ...
- DescriptionChicken polyclonal to Soluble TNF Receptor II
- Tested applicationsWB, ELISA more details
- Species reactivityReacts with: Human
- Immunogen
Purified recombinant human Enbrel
Properties
- FormLiquid
- Storage instructionsStore at +4°C.
- Storage bufferPreservative: 0.1% Sodium Azide
Constituents: 0.9% Sodium chloride -
Concentration information loading... - PurityIgY fraction
- Primary antibody notes Enbrel consists of the extracellular ligand binding portion of TNF Receptor II (TNFRII) linked to an immunoglobulin Fc chain. It binds to TNF alpha and blocks its interactions.
- Clonality Polyclonal
- IsotypeIgY
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab61908 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | |
| ELISA |
WB: 1/5000. Predicted molecular weight: 32 kDa and 75 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
- FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
- Sequence similaritiesContains 4 TNFR-Cys repeats.
- Post-translational
modificationsPhosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. - Cellular localizationSecreted and Cell membrane.
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Database links
- Entrez Gene: 7133 Human
- Omim: 191191 Human
- SwissProt: P20333 Human
- Unigene: 256278 Human
Target information above from: UniProt accession
P20333
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- CD120b antibodyp75 antibodyp75 TNF receptor antibody
- p75TNFR antibodyp80 TNF alpha receptor antibodyp80 TNF-alpha receptor antibodySoluble TNFR1B variant 1 antibodyTBP-2 antibodyTBPII antibodyTNF R II antibodyTNF R2 antibodyTNF R75 antibodyTNF-R2 antibodyTNF-RII antibodyTNFBR antibodyTNFR-II antibodyTNFR1B antibodyTNFR2 antibodyTNFR80 antibodyTnfrsf1b antibodyTNR1B_HUMAN antibodyTumor necrosis factor beta receptor antibodyTumor necrosis factor binding protein 2 antibodyTumor necrosis factor receptor 2 antibodyTumor necrosis factor receptor superfamily, member 1B antibodyTumor necrosis factor receptor type II antibodyTumor necrosis factor-binding protein 2 antibody
see all
References for Anti-Soluble TNF Receptor II antibody (ab61908)
ab61908 has not yet been referenced specifically in any publications.
