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Anti-Somatostatin antibody [8.F.258] (ab30788)

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Overview

Product name

Anti-Somatostatin antibody [8.F.258]
See all Somatostatin products (10) ...

Description

Rat monoclonal [8.F.258] to Somatostatin

Specificity

this antibody recognizes somatostatin. It partially cross reacts with somatostatin fragments, but does not cross react with enkephalins, other endorphins, Substance P or CGRP.

Tested applications

ELISA, IHC-Fr, IHC-Pmore details

Cross reactivity

Reacts with

Human

Immunogen

Somatostatin conjugated to Thyroglobulin (Human)

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.05% Thimerosal (merthiolate)
Constituents: 40% Glycerol

Concentration

Concentration information loading...

Purification notes

Tthis antibody is a purified cell culture supernatant.

Clonality

Monoclonal

Clone number

8.F.258

Isotype

IgG2b

Research areas

Developmental Biology >> Post embryonic development >> Growth hormones
Developmental Biology >> Lineage specification >> Endoderm
Stem Cells >> Lineage Markers >> Endoderm
Neuroscience >> Neurology process >> Neuroendocrinology >> GH Regulation
Neuroscience >> Neurotransmitter >> Neuropeptides >> Hormones

Applications

Show applications key

Our Abpromise guarantee covers the use of ab30788 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

  • IHC-Fr

     IHC-Fr: 1/25 - 1/100.

    IHC-Fr: 1/25 - 1/100.

  • ShowHide

    IHC-P

     IHC-P: 1/25 - 1/100.(Ant...Read more →

    IHC-P: 1/25 - 1/100.(Antigen retrieval is recommended. Suitable for IHC(PFA fixed) PMID 21343251.)

Target

Relevance

The cyclic tetradecapeptide somatostatin is widely distributed throughout the body and is an important regulator of endocrine and nervous system function. It exerts its biologic actions by binding to specific high affinity receptors on the cell surface. Somatostatin inhibits the release of somatotropin. Somatostatin has also been shown in sympathetic nerves, mucosal cells, myenteric nerves of the gastrointestinal tract, salivary glands and in some parafollicular cells of the thyroid. Somatostatin positive cells may also be present in medullary thyroid carcinomas, C cell hyperplasia, thymic and lung tumors and pulmonary small cell carcinomas.

Cellular localization

Secreted

Alternative names

  • Growth hormone release inhibiting factor antibody
  • SMST antibody
  • Somatostatin 14 antibody
  • Somatostatin 28 antibody
  • SST antibody
see all

Database links

References for Anti-Somatostatin antibody [8.F.258] (ab30788)

This product has been referenced in:

  • Cai Tet al. Expression of Insulinoma-Associated 2 (INSM2) in Pancreatic Islet Cells Is Regulated by the Transcription Factors Ngn3 and NeuroD1. Endocrinology 152:1961-9 (2011). IHC (PFA fixed); Human.Read more (PubMed: 21343251) »
  • Juhl Ket al. Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse. Diabetes 57:2755-61 (2008). IHC-Fr; Mouse.Read more (PubMed: 18599526) »

See all 3 publications for this product

Publishing research using ab30788? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"