HERG K+ channel blocker and Na+ channel inward current inhibitor
HERG K+ channel blocker (IC50 = 100-300 μM) and Na+ channel inward current inhibitor. Activates the AMPK signaling pathway. Inhibits Coxsackie B virus. Shows hepatoprotective and antiviral effects in vivo.
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Song CY et al. Sophocarpine alleviates hepatocyte steatosis through activating AMPK signaling pathway. Toxicol In Vitro27:1065-71 (2013).
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Zhang S et al. Sophocarpine attenuates the Na(+)-dependent Ca2(+) overload induced by Anemonia sulcata toxin-increased late sodium current in rabbit ventricular myocytes. J Cardiovasc Pharmacol60:357-66 (2012).
Read more (PubMed: 23064241) »