Overview
Product nameStAR proteinSee all StAR proteins and peptides ...
Protein descriptionRecombinant full length Human StAR (amino acids 1-286) with N terminal proprietary tag, 57.46kDa inclusive of tag. Purified from an in vitro wheat germ expression system. (UniProt ID = P49675).
Uniprot accessionP49675
Molecular weight57.460kDa inclusive of tags
Protein length286 amino acids
Expression hostWheat germ
Properties
FormLiquid
Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Storage bufferpH: 8.00
Constituents: 0.3% Glutathione, 0.79% Tris HCl
Concentration information loading...
Additional notesProtein concentration is above or equal to 0.05 µg/µl.
Sequence notesMLLATFKLCAGSSYRHMRNMKGLRQQAVMAISQELNRRAL GGPTPSTWINQVRRRSSLLGSRLEETLYSDQELAYLQQGE EAMQKALGILSNQEGWKKESQQDNGDKVMSKVVPDVGKVF RLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKI GKDTFITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLA GMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLT WLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESHPA SEARC
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab114371
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
|
Notes |
| ELISA |
ELISA: Use at an assay dependent concentration. |
| SDS-PAGE |
SDS-PAGE: Use at an assay dependent concentration. |
| WB |
WB: Use at an assay dependent concentration. (Recombinant protein). |
Protein info
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Alternative names
Cholesterol traffickerLuteinizing hormone induced proteinmitochondrial
Mitochondrial steroid acute regulatory proteinStARStAR related lipid transfer (START) domain containing 1STAR_HUMANStARD1START domain containing 1START domain containing protein 1START domain-containing protein 1Steroid acute regulatory proteinSteroidogenic acute regulatorSteroidogenic acute regulatory proteinSteroidogenic acute regulatory protein mitochondrial
see all
FunctionPlays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Tissue specificityExpressed in gonads, adrenal cortex and kidney.
PathwaySteroid metabolism; cholesterol metabolism.
Involvement in diseaseDefects in STAR are the cause of adrenal hyperplasia type 1 (AH1) [MIM:201710]. The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.
Sequence similaritiesContains 1 START domain.
Cellular localizationMitochondrion.
References for StAR protein (ab114371)
ab114371
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
SDS-PAGE - StAR protein (ab114371)12.5% SDS-PAGE showing ab114371 at approximately 57.46kDa stained with Coomassie Blue.