Streptococcus mutans Peptidoglycan antibody [2Q1861] (ab64557)

Product Name 

Streptococcus mutans Peptidoglycan antibody [2Q1861]

Product type 

Primary antibodies

Description 

Mouse monoclonal [2Q1861] to Streptococcus mutans Peptidoglycan

Immunogen 

Insoluble Peptidoglycan obtained by TCA/heat and ethanol extraction from Streptococus mutans BHT cells.

Species Reactivity 

Reacts with Streptococus mutans.

Specificity 

ab64557 is specific for the three-dimensional polymer complex structure of peptidoglycan. The epitopes appear to consist of discontinous glycan and/or amino acid residues and have not been fully defined. In a competitive immunoassay format, several compounds were found to be ineffective as inhibitors: muramyldipeptide, N-acetylglucosamine (NAG), chitin (polymer of NAG) and acid-hydrolyzed chitin (NAG oligomers).

Tested applications 
(see key)

Dot, ELISA, ICC

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
Dot: Use at an assay dependent dilution.
ELISA: Use at an assay dependent dilution.
ICC: Use at an assay dependent dilution.

Pretreatments, such as treatment with strong acid, for Gram-positive bacteria, or with a detergent, such as SDS, for Gram-negative bacteria, may be necessary to expose the epitopes.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Microbiology >> Organism >> Bacteria >> Gram positive bacteria >> Streptococcus

Relevance 

Streptococcus mutans plays a major role in tooth decay. It metabolizes sucrose to lactic acid creating an acidic environment in the mouth which contributes to the decay of the highly mineralized tooth enamel. S.mutans is one of a few specialized organisms equipped with receptors that help for better adhesion to the surface of teeth. Sucrose is utilized by S.mutans to produce a sticky, extracellular, dextran-based polysaccharide that allows them to cohere to each other forming plaque.

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

2Q1861

Isotype 

IgG3

Purity 

Ascites

Storage buffer 

Preservative: None
Constituents: Ascites

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

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