Anti-Streptolysin antibody [6D11] (ab23501)
Key features and details
- Mouse monoclonal [6D11] to Streptolysin
- Suitable for: ELISA
- Reacts with: Streptococcus
- Isotype: IgG1
Overview
-
Product name
Anti-Streptolysin antibody [6D11] -
Description
Mouse monoclonal [6D11] to Streptolysin -
Host species
Mouse -
Specificity
ab23501 is specific for oxidized streptolysin but cross reacts with untreated streptolysin -
Tested applications
Suitable for: ELISAmore details -
Species reactivity
Reacts with: Streptococcus -
Immunogen
Cysteine chloride oxidized streptolysin.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading...
-
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
6D11 -
Myeloma
x63-Ag8.653 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab23501 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ELISA |
1/400.
|
Notes |
---|
ELISA
1/400. |
Target
-
Relevance
Bacteria of the Streptococcus genera produce the exotoxin streptolysin. Anti-streptolysin antibody titers in patients are measured as a marker of inflammation. Streptolysin is also an important tool in cell biology due to its hemolytic activity and the ability to permeabilize plasma membranes. Sulfhydryl-activated toxin. Is able to lyse cholesterol containing membranes. Can be reversibly inactivated by oxidation. Cholesterol is the receptor for the binding of these toxins to eukaryotic cell membranes. -
Cellular localization
Secreted -
Alternative names
- Slo antibody
- Streptolysin O antibody
- Thiol activated cytolysin antibody
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (4)
ab23501 has been referenced in 4 publications.
- Lin CY et al. Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Streptococcus Infection. Front Cell Infect Microbiol 10:583137 (2020). PubMed: 33425778
- Horiuchi T et al. Floating chip mounting system driven by repulsive force of permanent magnets for multiple on-site SPR immunoassay measurements. Sensors (Basel) 12:13964-84 (2012). PubMed: 23202030
- Horiuchi T et al. Passive fluidic chip composed of integrated vertical capillary tubes developed for on-site SPR immunoassay analysis targeting real samples. Sensors (Basel) 12:7095-108 (2012). PubMed: 22969339
- Keyel PA et al. Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane. J Cell Sci 124:2414-23 (2011). ICC/IF, WB . PubMed: 21693578