Superoxide Dismutase 1 protein (Tagged) (ab84642)
Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
Our Abpromise guarantee covers the use of ab84642 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: Use at an assay dependent dilution. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).|
|SDS-PAGE||SDS-PAGE: Use at an assay dependent dilution.|
- ALSALS1Amyotrophic lateral sclerosis 1 adult
- Cu/Zn SODCu/Zn superoxide dismutaseHomodimerhSod1Indophenoloxidase AIPOAMn superoxide dismutaseSODSOD solubleSOD1SOD2SODCSODC_HUMANSuperoxide dismutase [Cu-Zn]Superoxide dismutase 1Superoxide dismutase 1 solubleSuperoxide dismutase Cu ZnSuperoxide dismutase cystolic
modificationsUnlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
The ditryptophan cross-link at Trp-33 is reponsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.
References for Superoxide Dismutase 1 protein (Tagged) (ab84642)
ab84642 has not yet been referenced specifically in any publications.