You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Superoxide Dismutase 2 protein (Tagged) (ab84639)

Submit an Abreview Submit a Question

Overview

  • Product nameSuperoxide Dismutase 2 protein (Tagged)See all SOD2 proteins and peptides ...
  • Protein descriptionRecombinant full length Human Superoxide Dismutase 2 with N-terminal proprietary tag; amino acids 1-222, MW 51kDa. NM_000636. Swiss ID P04179.
  • Expression hostE. coli

    • Properties

  • Purification notesPurity >90% as determined by densitometry.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab84639 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Indophenoloxidase BIPO BIPOB
        Manganese containing superoxide dismutaseManganese SODManganese superoxide dismutaseMangano superoxide dismutaseMn SODMn superoxide dismutaseMNSODMVCD6SOD 2SOD2SODM_HUMANSuperoxide dismutase [Mn] mitochondrialSuperoxide dismutase [Mn], mitochondrialSuperoxide dismutase 2 mitochondrial
      see all
  • FunctionDestroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • Involvement in diseaseGenetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
  • Sequence similaritiesBelongs to the iron/manganese superoxide dismutase family.
  • Post-translational
    modifications    Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
  • Cellular localizationMitochondrion matrix.

    • Target information above from: UniProt accession P04179 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Superoxide Dismutase 2 protein (Tagged) images

    • SDS-PAGE - Superoxide Dismutase 2 protein (Tagged) (ab84639)
      SDS-PAGE - Superoxide Dismutase 2 protein (Tagged) (ab84639)

    References for Superoxide Dismutase 2 protein (Tagged) (ab84639)

    ab84639 has not yet been referenced specifically in any publications.

    Publishing research using ab84639 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab84639 Submit a Question for ab84639

    There are currently no Abreviews or Questions for ab84639.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"