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Product name
Anti-Surf1 antibody [21H2BG4]
See all Surf1 products (3) ...
Description
Mouse monoclonal [21H2BG4] to Surf1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant Human Surf1
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: HBS
Concentration
Concentration information loading...
Purification notes
Near homogeneity as judged by SDS-PAGE. The antibody was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.
Clonality
Monoclonal
Clone number
21H2BG4
Isotype
IgG1
Light chain type
kappa
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Oxidative phosphorylation >> Complex IV
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Signal Transduction >> Metabolism >> Mitochondrial
Tags & Cell Markers >> Subcellular Markers >> Organelles >> Mitochondria
Applications
Show applications key
Our Abpromise guarantee covers the use of ab110256 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa.
Target
Function
Probably involved in the biogenesis of the COX complex.
Involvement in disease
Defects in SURF1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency.
Sequence similarities
Belongs to the SURF1 family.
Cellular localization
Mitochondrion inner membrane.
Target information above from: UniProt accessionQ15526
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- MS403 antibody
- OTTHUMP00000022473 antibody
- OTTHUMP00000022474 antibody
see all
Database links
- Entrez Gene: 6834 Human
- Omim: 185620 Human
- SwissProt: Q15526 Human
- Unigene: 512464 Human
References for Anti-Surf1 antibody [21H2BG4] (ab110256)
This product has been referenced in:
- Bastin J et al. Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components. J Clin Endocrinol Metab 93:1433-41 (2008).Read more (PubMed: 18211970) »
- Dell'agnello C et al. Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice. Hum Mol Genet 16:431-44 (2007). WB; Mouse.Read more (PubMed: 17210671) »
See all 2 publications for this product
Publishing research using ab110256? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"