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Anti-Survivin antibody (ab17392)

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Overview

Product name

Anti-Survivin antibody
See all Survivin products (18) ...

Description

Rabbit polyclonal to Survivin

Tested applications

IHC-Pmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

A synthetic peptide derived from the C-terminal region of human Survivin.

Positive control

Stomach

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 1% BSA

Purity

Tissue culture supernatant

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> IAPs
Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Neuroscience >> Cell Type Marker >> Glia marker >> Astrocyte marker
Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs

Applications

Show applications key

Our Abpromise guarantee covers the use of ab17392 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     

Application notes


IHC-P: 1/250 - 1/500. An incubation period of 30 minutes at room temperature is recommended. High temperature treatment of formalin-fixed tissue sections with 10mM citrate buffer, pH 6.0 must be performed prior to the immunostaining.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Tissue specificity

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.

Sequence similarities

Belongs to the IAP family.
Contains 1 BIR repeat.

Developmental stage

Expression is cell cycle-dependent and peaks at mitosis.

Domain

The BIR repeat is necessary and sufficient for HBXIP binding.

Post-translational
modifications

Ubiquitination is required for centrosomal targeting.
In vitro phosphorylation at Thr-117 by AURKB/STK12 prevents interaction with INCENP and localization to mitotic chromosomes.

Cellular localization

Cytoplasm. Nucleus. Chromosome. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.

Target information above from: UniProt accessionO15392 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • API4 antibody
  • Apoptosis Inhibitor 4 antibody
  • Apoptosis inhibitor survivin antibody
  • Apoptosis inhibitor4 antibody
  • Baculoviral IAP repeat containing 5 antibody
  • Baculoviral IAP repeat containing 5 antibody
  • Baculoviral IAP repeat containing protein 5 antibody
  • Baculoviral IAP repeat-containing protein 5 antibody
  • BIRC 5 antibody
  • BIRC 5 antibody
  • BIRC5 antibody
  • BIRC5_HUMAN antibody
  • EPR 1 antibody
  • EPR 1 antibody
  • IAP4 antibody
  • IAP4 antibody
  • SVV antibody
  • SVV antibody
  • TIAP antibody
  • TIAP antibody
see all

Database links

References for Anti-Survivin antibody (ab17392)

ab17392 has not yet been referenced specifically in any publications.

Publishing research using ab17392? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"