Anti-SynGAP antibody [EPR2883Y] (ab77235)
- Product nameAnti-SynGAP antibody [EPR2883Y]See all SynGAP primary antibodies ...
- DescriptionRabbit monoclonal [EPR2883Y] to SynGAP
- Tested applicationsWB, Flow Cyt, ICC/IF more details
- Species reactivityReacts with: Mouse, Rat, Human
A synthetic peptide corresponding to residues on the C terminus of human SynGAP
- Positive control
- Fetal brain lysate
- General notesProduced under U.S. Patent No. 5,675,063.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
- PurityTissue culture supernatant
- Clonality Monoclonal
- Clone numberEPR2883Y
- Research Areas
Our Abpromise guarantee covers the use of ab77235 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: 1/1000 - 1/5000. Predicted molecular weight: 147 kDa.|
|Flow Cyt||Flow Cyt: 1/50.|
|ICC/IF||ICC/IF: Use at an assay dependent dilution.|
- FunctionMajor constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
- Involvement in diseaseDefects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment. Autism can be present in some patients.
- Sequence similaritiesContains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.
modificationsPhosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption.
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Anti-SynGAP antibody [EPR2883Y] images
Anti-SynGAP antibody [EPR2883Y] (ab77235) at 1/1000 dilution + fetal brain lysate at 10 µg
HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size : 147 kDa
Observed band size : 147 kDa
Additional bands at : 50 kDa,55 kDa. We are unsure as to the identity of these extra bands.
References for Anti-SynGAP antibody [EPR2883Y] (ab77235)
ab77235 has not yet been referenced specifically in any publications.