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- Secondary antibodies
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Product name
Anti-Synapsin I (phospho S603) antibody
See all Synapsin I products (20) ...
Description
Rabbit polyclonal to Synapsin I (phospho S603)
Specificity
The antibody is specific for Synapsin I phosphorylated at Ser603.
Tested applications
Dot Blot, WBmore details
Cross reactivity
Reacts with
Rat
Immunogen
This antibody was developed against synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho-Ser603 of rat Synapsin I.
General notes
Aliquots may be taken without freeze/thawing due to the presence of 50% glycerol.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 100µg/ml BSA, 150mM Sodium Chloride, 10mM HEPES. pH 7.5
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
The antibody was purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Cell Type Marker >> Neuron marker >> Synapse marker
Neuroscience >> Neurotransmission >> Secretory Vesicles >> SNAPs & SNAREs
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Western blot - Synapsin I (phospho S603) antibody (ab13879)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab13879 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Dot Blot
Dot: 1/1000.Dot: 1/1000.
WB: 1/1000. Predicted molecular weight: 84.6 kDa.
Target
Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Involvement in disease
Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
Sequence similarities
Belongs to the synapsin family.
Post-translational
modifications
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization
Cell junction > synapse. Golgi apparatus.
Target information above from: UniProt accessionP17600
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Brain protein 4.1 antibody
- SYN 1 antibody
- SYN 1a antibody
see all
Database links
- Entrez Gene: 24949 Rat
- SwissProt: P09951 Rat
- Unigene: 9923 Rat
Anti-Synapsin I (phospho S603) antibody images:
Western blot - Synapsin I (phospho S603) antibody (ab13879)
Predicted band size : 84.6 kDa
Right lane-ab13879 at 1/1000 dilution detecting synapsin I by Western blot. Left lane-Peptide block.
References for Anti-Synapsin I (phospho S603) antibody (ab13879)
ab13879 has not yet been referenced specifically in any publications.
Publishing research using ab13879? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"