Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Related products
- Secondary antibodies
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-Synaptobrevin antibody [4H302]
See all Synaptobrevin products (6) ...
Description
Mouse monoclonal [4H302] to Synaptobrevin
Specificity
This antibody is reactive with the VAMP1 (amino acids 1-118) and the VAMP2 (amino acids 33-96)-GST fusion proteins expressed in E. coli.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Hamster, Cow, Human, Pig, Xenopus laevis
Immunogen
Tissue / cell preparation (Human). Synaptic vesicle-containing fractions which were immunoprecipitated from human brain homogenates using anti-human synaptophysin monoclonal antibodies
Positive control
Synaptic vesicle-containing fractions which were immunoprecipitated from human brain homogenates using other anti-human synaptophysin monoclonal antibody.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Ascites
Concentration
Concentration information loading...
Purity
Purified IgM
Clonality
Monoclonal
Clone number
4H302
Isotype
IgM
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Integration of energy
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Neuroscience >> Cell Type Marker >> Neuron marker >> Synapse marker
Neuroscience >> Neurotransmission >> Secretory Vesicles >> SNAPs & SNAREs
Applications
Show applications key
Our Abpromise guarantee covers the use of ab18015 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Detects a band of approximately 18 kDa.
Target
Relevance
Synaptobrevins are highly conserved between vertebrates and invertebrates. It is a major constituent of synaptic vesicles and peptidergic secretory granules in all neurons examined so far. In addition, it is present on secretory granules of neuroendocrine cells. Synaptobrevins, Syntaxins, and the 25 kDa synaptosomal associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.
Cellular localization
Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane. Single-pass type IV membrane protein. Cell junction > synapse > synaptosome. Isoform 3 is found in mitochondria, mitochondrial outer membrane.
Alternative names
- SYB antibody
- SYB1 antibody
- Synaptobrevin 1 antibody
see all
Database links
- Entrez Gene: 6843 Human
- Entrez Gene: 22317 Mouse
- Entrez Gene: 100519841 Pig
- Entrez Gene: 25624 Rat
- Omim: 185880 Human
- SwissProt: P23763 Human
- SwissProt: Q62442 Mouse
- SwissProt: Q63666 Rat
see all
References for Anti-Synaptobrevin antibody [4H302] (ab18015)
This product has been referenced in:
- Bate C & Williams A Neurodegeneration induced by clustering of sialylated glycosylphosphatidylinositols of prion proteins. J Biol Chem 287:7935-44 (2012). WB; Mouse.Read more (PubMed: 22262833) »
- Bate C & Williams A Amyloid-ß-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins. J Biol Chem 286:37955-63 (2011). WB; Mouse.Read more (PubMed: 21900234) »
See all 2 publications for this product
Publishing research using ab18015? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"