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Anti-Synaptojanin antibody [AC1] (ab111877)

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Overview

  • Product nameAnti-Synaptojanin antibody [AC1]See all Synaptojanin primary antibodies ...
  • Description
    Mouse monoclonal [AC1] to Synaptojanin
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Proline rich domain of a fusion protein comprising amino acids 1156-1286 of Rat Synaptojanin.

Properties

Applications

Our Abpromise guarantee covers the use of ab111877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/2000. Detects a band of approximately 170 kDa (predicted molecular weight: 172 kDa).

Target

  • FunctionInositol 5-phosphatase which has a role in clathrin-mediated endocytosis.
  • Tissue specificityConcentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals.
  • Sequence similaritiesBelongs to the synaptojanin family.
    In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family.
    Contains 1 RRM (RNA recognition motif) domain.
    Contains 1 SAC domain.
  • DomainBinds to EPS15 (a clathrin coat-associated protein) via a C-terminal domain containing three Asn-Pro-Phe (NPF) repeats.
    The C-terminal proline-rich region mediates binding to a variety of SH3 domain-containing proteins including AMPH, SH3GL1, SH3GL2, SH3GL3 and GRB2.
  • Cellular localizationCytoplasm.

    • Target information above from: UniProt accession O43426 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        4 antibody5-trisphosphate 5-phosphatase 1 antibodyINPP 5G antibody
        INPP5G antibodyKIAA0910 antibodyPolyphosphoinositide phosphatase antibodySynaptic inositol 1 4 5 trisphosphate 5 phosphatase 1 antibodySynaptic inositol 145 trisphosphate 5 phosphatase 1 antibodySynaptic inositol-1 antibodySynaptojanin 1 antibodySynaptojanin 1 polyphosphoinositide phosphatase antibodySynaptojanin-1 antibodySynaptojanin1 antibodySynj 1 antibodySynj1 antibodySYNJ1_HUMAN antibody
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    References for Anti-Synaptojanin antibody [AC1] (ab111877)

    ab111877 has not yet been referenced specifically in any publications.

    Publishing research using ab111877 ? Please let us know so that we can cite the reference in this datasheet

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