Overview

  • Product nameAnti-Synaptotagmin 1 antibody
    See all Synaptotagmin 1 primary antibodies
  • Description
    Sheep polyclonal to Synaptotagmin 1
  • Tested applicationsWB, IHC-Fr, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    A synthetic peptide as a part of rat and mouse Synaptotagmin 1 conjugated to an immunogenic carrier protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab72358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-Fr
IHC-P
  • Application notesIHC-P: 1/300 - 1/5000. Antigen retrieval is recommended.
    IHC-Fr: 1/300 - 1/5000.
    WB: 1/300 - 1/5000. Predicted molecular weight: 47 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
    • Sequence similaritiesBelongs to the synaptotagmin family.
      Contains 2 C2 domains.
    • DomainThe first C2 domain mediates Ca(2+)-dependent phospholipid binding.
      The second C2 domain mediates interaction with SV2A and STN2.
    • Cellular localizationCytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane. Cytoplasm. Synaptic vesicles and chromaffin granules.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp781D2042 antibody
      • FLJ42519 antibody
      • P65 antibody
      • SVP65 antibody
      • Synaptotagmin 2 antibody
      • Synaptotagmin I antibody
      • Synaptotagmin II antibody
      • Synaptotagmin-1 antibody
      • SYT antibody
      • SYT1 antibody
      • SYT1_HUMAN antibody
      • Syt2 antibody
      • SytI antibody
      see all

    References for Anti-Synaptotagmin 1 antibody (ab72358)

    ab72358 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab72358.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"