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Overview

  • Product nameAnti-Synaptotagmin 1 antibodySee all Synaptotagmin 1 primary antibodies ...
  • Description
    Sheep polyclonal to Synaptotagmin 1
  • Tested applicationsWB, IHC-Fr, IHC-P more details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    A synthetic peptide as a part of rat and mouse Synaptotagmin 1 conjugated to an immunogenic carrier protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab72358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
IHC-Fr
IHC-P
  • Application notesIHC-P: 1/300 - 1/5000. Antigen retrieval is recommended.
    IHC-Fr: 1/300 - 1/5000.
    WB: 1/300 - 1/5000. Predicted molecular weight: 47 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
    • Sequence similaritiesBelongs to the synaptotagmin family.
      Contains 2 C2 domains.
    • DomainThe first C2 domain mediates Ca(2+)-dependent phospholipid binding.
      The second C2 domain mediates interaction with SV2A and STN2.
    • Cellular localizationCytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane. Cytoplasm. Synaptic vesicles and chromaffin granules.

      • Target information above from: UniProt accession P21579 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          DKFZp781D2042 antibodyP65 antibodySVP65 antibody
          Synaptotagmin I antibodySynaptotagmin-1 antibodySYT antibodySYT1 antibodySYT1_HUMAN antibodySytI antibody
        see all

      References for Anti-Synaptotagmin 1 antibody (ab72358)

      ab72358 has not yet been referenced specifically in any publications.

      Publishing research using ab72358 ? Please let us know so that we can cite the reference in this datasheet

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