Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Overview
Product name
Anti-TANK antibody
See all TANK products (4) ...
Description
Rabbit polyclonal to TANK
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
A 14 amino acid peptide from near the carboxy terminus of human TANK.
Positive control
Daudi Cell Lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Growth Factors/Hormones >> TNF
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
-
Western blot - TANK antibody (ab47632)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab47632 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 2 µg/ml.Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa).
IHC-P: Use a concentration of 10 µg/ml
Target
Function
Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.
Tissue specificity
Ubiquitous.
Sequence similarities
Contains 1 C2H2-type zinc finger.
Post-translational
modifications
Phosphorylated by IKBKE.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionQ92844
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- I TRAF antibody
- I-TRAF antibody
- ITRAF antibody
see all
Database links
- Entrez Gene: 10010 Human
- Entrez Gene: 21353 Mouse
- Entrez Gene: 252961 Rat
- Omim: 603893 Human
- SwissProt: Q6NW12 Human
- SwissProt: Q92844 Human
- SwissProt: P70347 Mouse
- SwissProt: Q8R383 Mouse
see all
Anti-TANK antibody images:
Western blot - TANK antibody (ab47632)
Lane 1 : Anti-TANK antibody (ab47632) at 0.5 µg/ml
Lane 2 : Anti-TANK antibody (ab47632) at 1 µg/ml
Lane 3 : Anti-TANK antibody (ab47632) at 2 µg/ml
Lane 1 : Daudi Cell Lysate
Lane 2 : Daudi Cell Lysate
Lane 3 : Daudi Cell Lysate
Lysates/proteins at 15 µg per lane.
Predicted band size : 47 kDa
Observed band size : 55 kDa (why is the actual band size different from the predicted?)
References for Anti-TANK antibody (ab47632)
ab47632 has not yet been referenced specifically in any publications.
Publishing research using ab47632? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"