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Products:Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Overview
Product name
TANK peptide
See all TANK products (5) ...
Protein description
Synthetic peptide corresponding to 14 amino acids from near the carboxy terminus of human TANK. This peptide was used as an immunogen for ab47632 - TANK antibody.
Properties
Purification notes
Unpurified synthetic peptide with 60-70% purity.
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
Concentration
Concentration information loading...
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Growth Factors/Hormones >> TNF
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Applications
Show applications key
Our Abpromise guarantee covers the use of ab51555 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking
Application notes
BL: Use at an assay dependent dilution. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37oC.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.
Tissue specificity
Ubiquitous.
Sequence similarities
Contains 1 C2H2-type zinc finger.
Post-translational
modifications
Phosphorylated by IKBKE.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionQ92844
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for TANK peptide (ab51555)
ab51555 has not yet been referenced specifically in any publications.
Publishing research using ab51555? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"