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Product Name
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TAP1 antibody
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See all TAP1 antibodies (7)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to TAP1
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Immunogen
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Transporter Associated with Antigen Processing (TAP1 ) peptide corresponding to the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
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Reacts with
(species key)
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Hu
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Specificity
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No reaction was observed against TAP-II in ELISA or immunoblotting.
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Tested applications
(see key)
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent concentration.
WB: Use at an assay dependent concentration.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane
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Research areas
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Signal Transduction >> Adapters >> Transmembrane
Immunology >> Adaptive Immunity >> MHC >> Class I
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Relevance
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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
Transporter Associated with Antigen Processing (TAP) is involved in the delivery of peptides generated from proteolytic degradation of cytoplasmic antigens across the ER to class I MHC.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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0.02M K Phosphate, 0.15M NaCl, 0.01% Sodium Azide, pH7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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This product was prepared from monospecific antiserum by delipidation, salt fractionation and ion exchange chromatography. A single precipitin arc was observed against anti-Rabbit Serum when assayed by immunoelectrophoresis.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this TAP1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to TAP1
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TAP1 antibody - more information
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Customer reviews (feedback) regarding TAP1 antibody |
Customer FAQs regarding TAP1 antibody |
Protocols for TAP1 antibody |
Price and availability of products related to TAP1 antibody |
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Contact Abcam with a Technical Enquiry about TAP1 antibody |
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