TAPI-2, MMP and ADAM inhibitor (ab142219)
Key features and details
- Broad spectrum MMP and ADAM inhibitor
- CAS Number: 187034-31-7
- Purity: > 95%
Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TAPI-2, MMP and ADAM inhibitor -
Description
Broad spectrum MMP and ADAM inhibitor -
Alternative names
- TNF Protease Inhibitor 2
- Tumor necrosis factor alpha protease inhibitor 2
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Purity
> 95% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 2069 TAPI-2. 2069-1 is the same size as the 1 mg size of ab142219.
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CAS Number
187034-31-7 -
Chemical structure
Properties
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Chemical name
N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
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Molecular weight
415.28 -
Molecular formula
C19H37N5O5 -
PubChem identifier
10093303 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in water to 50 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)CC(CC(=O)NO)C(=O)NC(C(=O)NC(C)C(=O)NCCN)C(C)(C)C -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab142219 has been referenced in 3 publications.
- Zheng X et al. ADAM17 promotes glioma cell malignant phenotype. Mol Carcinog 51:150-64 (2012). PubMed: 21480393
- Blair CR et al. The type III TGF-ß receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease ?-secretase. Biochim Biophys Acta 1813:332-9 (2011). PubMed: 21167215
- Arribas J et al. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J Biol Chem 271:11376-82 (1996). PubMed: 8626692