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Overview

  • Product nameTBR2 / Eomes peptideSee all TBR2 / Eomes proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 650 to the C-terminus of Mouse TBR2 / Eomes. (Note: the amino acid sequence is proprietary) This peptide was used as an immunogen for ab23345 - TBR2 / Eomes antibody.
  • Protein length688 amino acids

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab23345.

    • Protein info

    • Alternative names
        EomesEOMES_HUMANEomesodermin
        Eomesodermin homologt box brain 2T-box brain protein 2T-brain-2Tbr 2TBR-2
      see all
  • FunctionFunctions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
  • Tissue specificityExpressed in CD8+ T-cells.
  • Involvement in diseaseNote=A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.
  • Sequence similaritiesContains 1 T-box DNA-binding domain.
  • Developmental stageDetected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within the mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession O95936 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for TBR2 / Eomes peptide (ab25698)

    ab25698 has not yet been referenced specifically in any publications.

    Publishing research using ab25698 ? Please let us know so that we can cite the reference in this datasheet

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