Overview

  • Product name
  • Description
    Mouse polyclonal to TC10
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Full length protein corresponding to amino acids 1-205 of Human TC10 (NP_036381.2).

  • Positive control
    • TC10 transfected 293T cell lysate. HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab168645 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 23 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
  • Sequence similarities
    Belongs to the small GTPase superfamily. Rho family.
  • Post-translational
    modifications
    May be post-translationally modified by both palmitoylation and polyisoprenylation.
  • Cellular localization
    Cytoplasm. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARHQ antibody
    • Ras homolog gene family member Q antibody
    • RAS like family 7 member A antibody
    • Ras like protein family member 7A antibody
    • Ras like protein TC10 antibody
    • Ras related GTP binding protein TC10 antibody
    • Ras-like protein family member 7A antibody
    • Ras-like protein TC10 antibody
    • RASL7A antibody
    • Rho related GTP binding protein RhoQ antibody
    • Rho-related GTP-binding protein RhoQ antibody
    • Rhoq antibody
    • RHOQ_HUMAN antibody
    • TC10A antibody
    see all

Images

  • All lanes : Anti-TC10 antibody (ab168645) at 1 µg/ml

    Lane 1 : TC10 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 23 kDa
  • Immunofluorescence analysis of HeLa cells, labeling TC10 with ab168645 at 10 µg/ml.

References

This product has been referenced in:
  • Mayer S  et al. Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission. Proc Natl Acad Sci U S A 110:20795-800 (2013). Read more (PubMed: 24297911) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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