You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAnti-TCCR antibodySee all TCCR primary antibodies ...
  • Description
    Rabbit polyclonal to TCCR
  • Tested applicationsICC/IF, IHC-P, WB more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide: SGYEKHFLPTPEELG, corresponding to amino acids 611-625 of Human TCCR.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlHuman spleen tissue lysate.
  • General notesStable for one year.

Properties

Applications

Our Abpromise guarantee covers the use of ab5996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF ICC/IF: Use a concentration of 20 µg/ml.
IHC-P IHC-P: Use a concentration of 5 µg/ml.
WB WB: Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 70 kDa.Can be blocked with TCCR peptide (ab39872).

Target

  • FunctionReceptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
  • Tissue specificityHighly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 3 fibronectin type-III domains.
  • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q6UWB1 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Class I cytokine receptor antibodyCRL1 antibodyCytokine receptor-like 1 antibody
        I27RA_HUMAN antibodyIL-27 receptor subunit alpha antibodyIL-27R subunit alpha antibodyIL-27R-alpha antibodyIL-27RA antibodyIL27R alpha antibodyIL27R antibodyIl27ra antibodyInterleukin 27 receptor alpha chain precursor antibodyInterleukin 27 receptor antibodyInterleukin-27 receptor subunit alpha antibodyProtein CRL1 antibodyT cell cytokine receptor type 1 antibodyTCCR antibodyType 1 T cell cytokine receptor antibodyType I T-cell cytokine receptor antibodyWSX-1 antibodyWSX1 antibodyZcytoR1 antibody
      see all

    Anti-TCCR antibody images

    • Western blot - TCCR antibody (ab5996)
      Western blot - TCCR antibody (ab5996)
      Anti-TCCR antibody (ab5996) at 1 µg/ml + Human spleen tissue lysate
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TCCR antibody (ab5996)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TCCR antibody (ab5996)

      ab5996 at 5µg/ml staining TCCR in human spleen tissue by IHC

    • Immunocytochemistry/ Immunofluorescence-Anti-TCCR antibody(ab5996)
      Immunocytochemistry/ Immunofluorescence-Anti-TCCR antibody(ab5996)
      Immunofluorescence of TCCR in Human Spleen cells using ab5996 at 20 ug/ml.

    References for Anti-TCCR antibody (ab5996)

    This product has been referenced in:
    • Sugiyama N  et al. Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1). Ann Rheum Dis 67:1461-7 (2008). WB ; Mouse . Read more (PubMed: 18094002) »
    • Takeda A  et al. WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation. Int Immunol 17:889-97 (2005). Read more (PubMed: 15908443) »

    See all 2 Publications for this product

    Publishing research using ab5996 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab5996 Submit a Question for ab5996

    There are currently no Abreviews or Questions for ab5996.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"