Anti-TCEA1 antibody (ab113215)

Overview

• Product nameAnti-TCEA1 antibodySee all TCEA1 primary antibodies ...
• Description
  Rabbit polyclonal to TCEA1
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide from a region between residues 1 to 50 of Human TCEA1 (NP_006747.1).

• Positive controlHuman breast carcinoma and Human colon carcinoma FFPE slides.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium azide
  Constituents: 0.1% BSA, 99.81% Tris buffered saline
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Elongation factors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Polymerase associated factors
  • Pol II Transcription
  • Other

Applications

Target

• FunctionNecessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
• Involvement in diseaseNote=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
• Sequence similaritiesBelongs to the TFS-II family.
  Contains 1 TFIIS central domain.
  Contains 1 TFIIS N-terminal domain.
  Contains 1 TFIIS-type zinc finger.
• Post-translational
  modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
• Cellular localizationNucleus.

Target information above from: UniProt accession P23193 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 6917 Human
  • Omim: 601425 Human
  • SwissProt: P23193 Human
  • Unigene: 491745 Human

• Alternative names
  GTF2S antibodySII antibodyTCEA antibody

  Tcea1 antibodyTCEA1_HUMAN antibodyTF2S antibodyTFIIS antibodytranscription elongation factor A (SII), 1 antibodyTranscription elongation factor A protein 1 antibodyTranscription elongation factor S-II protein 1 antibodyTranscription elongation factor TFIIS.o antibody

  see all

Anti-TCEA1 antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TCEA1 antibody (ab113215)
  ab113215 at a 1/100 dilution staining TCEA1 in Human breast carcinoma by immunohistochemistry (FFPE section). Detection: DAB staining