You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameTCF4 peptideSee all TCF4 proteins and peptides ...
  • Protein descriptionSynthetic peptide of Human TCF4.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab84168 - .
  • Protein length19 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab84168.

    • Protein info

    • Alternative names
        bHLHb19Class B basic helix-loop-helix protein 19E2 2
        Immunoglobulin transcription factor 2ITF 2ITF-2ITF2ITF2_HUMANMGC149723MGC149724PTHSSEF 2SEF-2SEF2SEF2 1SEF2 1ASEF2 1BSL3 3 enhancer factor 2SL3-3 enhancer factor 2TCF 4TCF-4TCF4Transcription factor 4
      see all
  • FunctionTranscription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
  • Tissue specificityExpressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain.
  • Involvement in diseaseDefects in TCF4 are a cause of Pitt-Hopkins syndrome (PTHS) [MIM:610954]. PTHS is a rare syndromic encephalopathy characterized by severe psychomotor delay, epilepsy, daily bouts of diurnal hyperventilation starting in infancy, mild postnatal growth retardation, postnatal microcephaly, and distinctive facial features. Since most hitherto reported cases have been sporadic, with males and females equally affected, PTHS is regarded as an autosomal dominant condition.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • Domainthe 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession P15884 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for TCF4 peptide (ab93787)

    ab93787 has not yet been referenced specifically in any publications.

    Publishing research using ab93787 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab93787 Submit a Question for ab93787

    There are currently no Abreviews or Questions for ab93787.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"