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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-TCN2 antibody
See all TCN2 products (2) ...
Description
Mouse monoclonal to TCN2
Tested applications
WB, Indirect ELISAmore details
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Human
Immunogen
GST-tagged recombinant full length protein, corresponding to amino acids 1-401 of Human TCN2
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Signal Transduction >> Metabolism >> Vitamins / Minerals
Cardiovascular >> Blood >> Serum Proteins
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Western blot - TCN2 antibody (ab76638)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab76638 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Indirect ELISA
Application notes
I-ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 47 kDa.
Note: This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Involvement in disease
Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.
Sequence similarities
Belongs to the eukaryotic cobalamin transport proteins family.
Cellular localization
Secreted.
Target information above from: UniProt accessionP20062
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- D22S676 antibody
- D22S750 antibody
- II antibody
see all
Database links
- Entrez Gene: 6948 Human
- Omim: 275350 Human
- SwissProt: 275350 Human
- SwissProt: P20062 Human
- Unigene: 417948 Human
Anti-TCN2 antibody images:
Western blot - TCN2 antibody (ab76638)
Anti-TCN2 antibody (ab76638) at 5 µg/ml + immunogen (GST-tagged recombinant full length Human TCN2) at 0.2 µg
Secondary
Goat Anti-Mouse IgG (H&L) HRP-conjugated at 1/5000 dilution
Predicted band size : 47 kDa
Observed band size : 73 kDa (why is the actual band size different from the predicted?)
MW of GST tag: 26 kDa
References for Anti-TCN2 antibody (ab76638)
ab76638 has not yet been referenced specifically in any publications.
Publishing research using ab76638? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"