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Products:Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin
Overview
Product name
Anti-TCP1 alpha antibody [22b]
See all TCP1 alpha products (11) ...
Description
Rat monoclonal [22b] to TCP1 alpha
Specificity
This antibody is monospecific for TCP1, not reacting with similar proteins.
Tested applications
IP, WBmore details
Cross reactivity
Reacts with
Mouse, Rat, Chicken, Hamster, Dog, Human
Does not react with
Saccharomyces cerevisiae, Xenopus laevis, Monkey
Immunogen
C terminal half of the full length murine TCP protein.
Epitope
553 LDD-COOH
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
22b
Myeloma
Y3/Ag1.2.3
Isotype
IgG2a
Research areas
Signal Transduction >> Protein Trafficking >> Chaperones >> Other Chaperones
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin
Applications
Show applications key
Our Abpromise guarantee covers the use of ab31911 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 60 kDa.
Target
Function
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Sequence similarities
Belongs to the TCP-1 chaperonin family.
Cellular localization
Cytoplasm. Cytoplasm > cytoskeleton > centrosome.
Target information above from: UniProt accessionP17987
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AI528772 antibody
- c-cpn antibody
- CCT alpha antibody
see all
Database links
- Entrez Gene: 484064 Dog
- Entrez Gene: 6950 Human
- Entrez Gene: 21454 Mouse
- Entrez Gene: 24818 Rat
- Omim: 186980 Human
- SwissProt: P17987 Human
- SwissProt: P11983 Mouse
- SwissProt: P28480 Rat
see all
References for Anti-TCP1 alpha antibody [22b] (ab31911)
This product has been referenced in:
- Zhu Het al. Proteomic analysis of testis biopsies in men treated with transient scrotal hyperthermia reveals the potential targets for contraceptive development. Proteomics 10:3480-93 (2010). WB; Human.Read more (PubMed: 20815088) »
- Harrison-Lavoie KJet al. A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins. EMBO J 12:2847-53 (1993).Read more (PubMed: 8335000) »
See all 3 publications for this product
Publishing research using ab31911? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"