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Products:Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol II Transcription >> Other
Overview
Product name
Anti-TEAD4 antibody
See all TEAD4 products (5) ...
Description
Mouse monoclonal to TEAD4
Tested applications
Cross reactivity
Reacts with
Mouse, Recombinant Fragment
Immunogen
Recombinant fragment, corresponding to amino acids 151-261 of Human TEAD4
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Cardiovascular >> Heart >> Cardiogenesis >> Transcription factors/regulators
Epigenetics and Nuclear Signaling >> Transcription >> Transcription Factors
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol II Transcription >> Other
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Western blot - TEAD4 antibody (ab58310)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab58310 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Tissue specificity
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Sequence similarities
Contains 1 TEA DNA-binding domain.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ15561
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- EFTR 2 antibody
- EFTR2 antibody
- hRTEF 1B antibody
see all
Database links
- Entrez Gene: 21679 Mouse
- SwissProt: Q62296 Mouse
- Unigene: 14774 Mouse
Anti-TEAD4 antibody images:
Western blot - TEAD4 antibody (ab58310)
TEAD4 antibody (ab58310) at 1ug/lane + HeLa cell lysate at 25ug/lane.
References for Anti-TEAD4 antibody (ab58310)
This product has been referenced in:
- Home Pet al. GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression. J Biol Chem 284:28729-37 (2009). WB; Mouse.Read more (PubMed: 19700764) »
See 1 publication for this product
Publishing research using ab58310? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"