Overview
Product nameTEM8 peptideSee all TEM8 proteins and peptides ...
Protein description13 amino acids near the center of human TEM8.
This peptide was used as an immunogen for ab21270 - TEM8 antibody.
Properties
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
Concentration information loading...
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab41852
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
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Notes |
| Blocking |
BL: Use at an assay dependent dilution. An equal volume usually completely blocks antibody activity in Western blot. |
Protein info
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Alternative names
Anthrax toxin receptor 1Anthrax toxin receptor 1 precursorANTR1_HUMAN
ANTXR 1ANTXR1ATRFLJ10601FLJ11298FLJ21776TEM 8Tumor Endothelial Marker 8Tumor endothelial marker 8 precursor
see all
FunctionPlays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
Tissue specificityDetected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
Involvement in diseaseDefects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
Sequence similaritiesBelongs to the ATR family.
Contains 1 VWFA domain.
DomainBinding to PA occurs through the VWA domain.
Cellular localizationCell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
References for TEM8 peptide (ab41852)
ab41852
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
