Anti-TEP1 antibody (ab64189)

Overview

• Product nameAnti-TEP1 antibody
• Description
  Rabbit polyclonal to TEP1
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  A 20 amino acid synthetic peptide from near the amino terminus of Human TEP1.

• Epitope20 amino acid peptide from near the amino terminus of Human TEP1.
• Positive controlHuman skin tissue. Human breast tissue.

Properties

• FormLiquid
• Storage instructionsStore at +4°C.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Chromosome Structure
  • Telomeres

Applications

Target

• RelevanceTelomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.
• Cellular localizationNuclear (probable). Telomere.
• Database links
  • Entrez Gene: 7011 Human
  • Entrez Gene: 7011 Human
  • Entrez Gene: 21745 Mouse
  • Entrez Gene: 64523 Rat
  • SwissProt: Q99973 Human
  • SwissProt: Q99973 Human
  • SwissProt: P97499 Mouse
  • SwissProt: O08653 Rat

  • Unigene: 508835 Human
  • Unigene: 318736 Mouse
  • Unigene: 5890 Rat

  see all

• Alternative names
  p240 antibodyp80 telomerase homolog antibodyTelomerase associated protein 1 antibody

  Telomerase protein component 1 antibodyTLP1 antibodyTP1 antibodyTROVE domain family, member 1 antibodyTROVE1 antibodyVAULT2 antibody

  see all

Anti-TEP1 antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TEP1 antibody (ab64189)
  ab64189 (5ug/ml) staining TEP1 in human skin tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TEP1 antibody (ab64189)
  ab64189 (5ug/ml) staining TEP1 in human breast tissue by immunohistochemistry using formalin-fixed, paraffin embedded tissue.