Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab106774 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 40 kDa).

Target

  • FunctionS-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
  • Tissue specificityUbiquitously expressed.
  • Involvement in diseaseNote=Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.
  • Sequence similaritiesBelongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
  • Cellular localizationMitochondrion.
  • Target information above from: UniProt accession Q8WVM0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • N'-adenosyl(rRNA) dimethyltransferase 1 antibody
    • CGI75 antibody
    • Dimethyladenosine transferase 1 antibody
    • Dimethyladenosine transferase 1, mitochondrial antibody
    • h-mtTFB antibody
    • h-mtTFB1 antibody
    • hmtTFB antibody
    • hmtTFB1 antibody
    • hTFB1M antibody
    • hTFB1M antibody
    • Mitochondrial 12S rRNA dimethylase 1 antibody
    • Mitochondrial 12S rRNA dimethylase 1 antibody
    • mitochondrial antibody
    • Mitochondrial dimethyladenosine transferase 1 antibody
    • Mitochondrial transcription factor B1 antibody
    • Mitochondrial transcription factor B1 antibody
    • mtTFB1 antibody
    • mtTFB1 antibody
    • S-adenosylmethionine-6-N' antibody
    • Tfb1m antibody
    • TFB1M_HUMAN antibody
    • Transcription factor B1 mitochondrial antibody
    see all

Anti-TFB1M antibody images

  • Anti-TFB1M antibody (ab106774) at 0.3 µg/ml + A431 cell lysate at 35 µg
    developed using the ECL technique

    Predicted band size : 40 kDa
    Observed band size : 38 kDa (why is the actual band size different from the predicted?)


    Exposure time : 1 hour

References for Anti-TFB1M antibody (ab106774)

ab106774 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106774.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"