Anti-TFB1M antibody (ab106774)

Overview

• Product nameAnti-TFB1M antibodySee all TFB1M primary antibodies ...
• Description
  Goat polyclonal to TFB1M
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide: C-ELKRRKSKNEEKE, corresponding to C terminal amino acids 325-337 of Human TFB1M (NP_057104.2)

  Run BLAST with Run BLAST with
• Positive controlA431 cell lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Nucleotide metabolism
  • Molecular processes
  • Mitochondrial transcription

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial Biogenesis

  • Tags & Cell Markers
  • Subcellular Markers
  • Organelles
  • Mitochondria

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

Applications

Target

• FunctionS-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
• Tissue specificityUbiquitously expressed.
• Involvement in diseaseNote=Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.
• Sequence similaritiesBelongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
• Cellular localizationMitochondrion.

Target information above from: UniProt accession Q8WVM0 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 51106 Human
  • Omim: 607033 Human
  • SwissProt: Q8WVM0 Human
  • Unigene: 279908 Human

• Alternative names
  N'-adenosyl(rRNA) dimethyltransferase 1 antibodyCGI75 antibodyDimethyladenosine transferase 1 antibody

  Dimethyladenosine transferase 1, mitochondrial antibodyh-mtTFB antibodyh-mtTFB1 antibodyhmtTFB antibodyhmtTFB1 antibodyhTFB1M antibodyhTFB1M antibodyMitochondrial 12S rRNA dimethylase 1 antibodyMitochondrial 12S rRNA dimethylase 1 antibodymitochondrial antibodyMitochondrial dimethyladenosine transferase 1 antibodyMitochondrial transcription factor B1 antibodyMitochondrial transcription factor B1 antibodymtTFB1 antibodymtTFB1 antibodyS-adenosylmethionine-6-N' antibodyTfb1m antibodyTFB1M_HUMAN antibodyTranscription factor B1 mitochondrial antibody

  see all

Anti-TFB1M antibody images

• 

  Western blot - TFB1M antibody (ab106774)
  Anti-TFB1M antibody (ab106774) at 0.3 µg/ml + A431 cell lysate at 35 µg
  developed using the ECL technique
  
  Predicted band size : 40 kDa
  Observed band size : 38 kDa (why is the actual band size different from the predicted?)
  
  
  Exposure time : 1 hour