Overview

  • Product name
    TG003
  • Description
    Potent, selective ATP-competitive Clk1/Sty inhibitor
  • Biological description
    Potent, selective ATP-competitive Clk1/Sty inhibitor (IC50 values are 20, 200, 15 nM and >10 μM for Clk1/Sty, Clk2, Clk4 and Clk3 respectively). Blocks alternative splicing of PKCβII and expression of PPARγ1 and PPARγ2. Shows analgesic effects in vivo. Centrally active.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Kurihara T  et al. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain 10:17 (2014). Read more (PubMed: 24612480) »
  • Li P  et al. Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes. PLoS One 8:e53268 (2013). Read more (PubMed: 23308182) »
  • Hagiwara M Alternative splicing: a new drug target of the post-genome era. Biochim Biophys Acta 1754:324-31 (2005). Read more (PubMed: 16260193) »
  • Muraki M  et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem 279:24246-54 (2004). Read more (PubMed: 15010457) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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