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Anti-TGF beta 1 antibody (ab46780)

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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab46780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
ELISA
  • Application notesELISA: 1/2000 - 1/5000.
    WB: 1/2000 - 1/5000. Predicted molecular weight: 47 kDa for the unprocessed precursor; 25 kDa for the mature protein; 13KDa for degraded or cleaved protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionMultifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
    • Tissue specificityHighly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
    • Involvement in diseaseDefects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
    • Sequence similaritiesBelongs to the TGF-beta family.
    • Post-translational
      modifications      Glycosylated.
      The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.

      • Target information above from: UniProt accession P01137 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      see all
    • Alternative names
        Camurati Engelmann disease antibodyCED antibodyDiaphyseal dysplasia 1 progressive antibody
        DPD1 antibodyLAP antibodyLatency-associated peptide antibodyTGF beta 1 antibodyTGF beta antibodyTGF beta 1 protein antibodyTGF-beta 1 protein antibodyTGF-beta-1 antibodyTGF-beta-5 antibodyTGF-beta1 antibodyTGFB 1 antibodyTGFB antibodyTgfb-1 antibodyTGFB1 antibodyTGFB1_HUMAN antibodyTGFbeta antibodyTGFbeta1 antibodyTransforming Growth Factor b1 antibodyTransforming Growth Factor beta 1 antibodyTransforming growth factor beta 1a antibodytransforming growth factor beta-1 antibodytransforming growth factor, beta 1 antibody
      see all

    Anti-TGF beta 1 antibody images

    • Western blot
      Western blot
      All lanes : Anti-TGF beta 1 antibody (ab46780) at 1/2000 dilution

      Lane 1 : TGF beta 1 protein (Active) (ab50036) at 0.1 µg
      Lane 2 : TGF beta 1 protein (Active) (ab50036) at 0.01 µg

      Secondary
      Goat polyclonal Secondary Antibody to Chicken IgY - H&L (HRP) (ab6877) at 1/5000 dilution
      developed using the ECL technique

      Performed under reducing conditions.

      Exposure time : 2 minutes

    References for Anti-TGF beta 1 antibody (ab46780)

    ab46780 has not yet been referenced specifically in any publications.

    Publishing research using ab46780 ? Please let us know so that we can cite the reference in this datasheet

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    Coul you suggest antibodies for TGF beat 1, Ki67 anf TGGS protein?

    Thank you for contacting us.

    We do not have mouse monoclonal antibodies to the target you are requested. However we do have following antibodies available;

    ab9758; http://www.abcam.com/TGF-beta-1-antibody-ab9758.html

    ab46780; ht...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"