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TGF beta 1 protein (His tag) (ab82992)

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Overview

  • Product nameTGF beta 1 protein (His tag)See all TGF beta 1 proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 279-390 of Human TGF beta 1 with an amino-terminal hexahistidine tag; 112 amino acids, 13kDa. Swiss ID = P01137
  • Expression hostE. coli

    • Properties

  • FormLiquid
  • Storage instructionsStore at -20°C. Stable for 12 months at -20°C
  • Storage bufferPreservative: None
    Constituents: 1x Laemmli Buffer (2.5% Glycerol, 1% SDS, 0.1% Bromophenol blue, 50mM DTT, 25mM Tris HCl, pH 6.8)
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab82992 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
  • Application notesWB: Use at an assay dependent dilution. Predicted molecular weight: 44 kDa.
    Single band observed on Western blot.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        CEDDPD1LAP
        Latency-associated peptideTGF betaTGF beta 1TGF beta 1 proteinTGF-beta 1 proteinTGF-beta-1TGF-beta-5TGF-beta1TGFBTgfb-1TGFB1TGFB1_HUMANTGFbetaTGFbeta1Transforming Growth Factor b1Transforming Growth Factor beta 1Transforming growth factor beta 1atransforming growth factor beta-1transforming growth factor, beta 1
      see all
  • FunctionMultifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
  • Tissue specificityHighly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
  • Involvement in diseaseDefects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
  • Sequence similaritiesBelongs to the TGF-beta family.
  • Post-translational
    modifications    Glycosylated.
    The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession P01137 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for TGF beta 1 protein (His tag) (ab82992)

    ab82992 has not yet been referenced specifically in any publications.

    Publishing research using ab82992 ? Please let us know so that we can cite the reference in this datasheet

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    Latent inactive form of TGF beta.

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    I have now received an answer from lab. The protein ab82991 can be used in ELISA but the biological activity of this protein has not been tested so we unfortunately will not be able to confirm whether the protein is ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"