TGFBI protein (Human) (ab86989)
Constituents: 20% Glycerol, 20mM Tris HCl, 1mM EDTA, 0.1mM PMSF, pH 8.0
Our Abpromise guarantee covers the use of ab86989 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|SDS-PAGE||SDS-PAGE: Use at an assay dependent dilution.|
RGD containing collagen associated proteinAI181842AI747162
- Beta igBeta ig h3Beta ig-h3BGH3_HUMANBig h3BIGH3CDB1CDG2CDGG1CSDCSD1CSD2CSD3EBMDKerato epithelinKerato-epithelinLCD1MGC150270RGD CAPRGD-CAPRGD-containing collagen-associated proteinTGFBITGFBI transforming growth factor, beta induced, 68kDaTransforming growth factor beta induced protein ig h3Transforming growth factor-beta-induced protein ig-h3
Defects in TGFBI are the cause of corneal dystrophy Groenouw type 1 (CDGG1) [MIM:121900]; also known as corneal dystrophy granular type. Inheritance is autosomal dominant. Corneal dystrophies show progressive opacification of the cornea leading to severe visual handicap.
Defects in TGFBI are the cause of corneal dystrophy lattice type 1 (CDL1) [MIM:122200]. Inheritance is autosomal dominant.
Defects in TGFBI are a cause of corneal dystrophy Thiel-Behnke type (CDTB) [MIM:602082]; also known as corneal dystrophy of Bowman layer type 2 (CDB2).
Defects in TGFBI are the cause of Reis-Buecklers corneal dystrophy (CDRB) [MIM:608470]; also known as corneal dystrophy of Bowman layer type 1 (CDB1).
Defects in TGFBI are the cause of lattice corneal dystrophy type 3A (CDL3A) [MIM:608471]. CDL3A clinically resembles to lattice corneal dystrophy type 3, but differs in that its age of onset is 70 to 90 years. It has an autosomal dominant inheritance pattern.
Defects in TGFBI are the cause of Avellino corneal dystrophy (ACD) [MIM:607541]. ACD could be considered a variant of granular dystrophy with a significant amyloidogenic tendency. Inheritance is autosomal dominant.
Contains 4 FAS1 domains.
modificationsGamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
TGFBI protein (Human) images
15% SDS-PAGE showing ab86989 at approximately 19.9kDa (3µg).
Note: Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.
References for TGFBI protein (Human) (ab86989)
ab86989 has not yet been referenced specifically in any publications.