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Overview

  • Product nameTGFBI protein (Human)See all TGFBI proteins and peptides ...
  • Protein descriptionRecombinant fragment corresponding to amino acids 502-683 of Human TGFBI (containg the FAS1 4 domain); 182 amino acids, 19.9 kDa. Swiss ID = Q15582
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab86989 is purified using conventional chromatography techniques.
  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 1mM EDTA, 0.1mM PMSF, pH 8.0
  • Concentration information loading...
  • Additional notesEndotoxin Level: < 1.0 EU per 1 µg of protein (determined by LAL method).
  • Sequence notesMGTVMDVLKG DNRFSMLVAA IQSAGLTETL NREGVYTVFA PTNEAFRALP PRERSRLLGD AKELANILKY HIGDEILVSG GIGALVRLKS LQGDKLEVSL KNNVVSVNKE PVAEPDIMAT NGVVHVITNV LQPPANRPQE RGDELADSAL EIFKQASAFS RASQRSVRLA PVYQKLLERM KH
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab86989 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        RGD containing collagen associated proteinAI181842AI747162
        Beta igBeta ig h3Beta ig-h3BGH3_HUMANBig h3BIGH3CDB1CDG2CDGG1CSDCSD1CSD2CSD3EBMDKerato epithelinKerato-epithelinLCD1MGC150270RGD CAPRGD-CAPRGD-containing collagen-associated proteinTGFBITGFBI transforming growth factor, beta induced, 68kDaTransforming growth factor beta induced protein ig h3Transforming growth factor-beta-induced protein ig-h3
      see all
  • FunctionBinds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation.
  • Tissue specificityHighly expressed in the corneal epithelium.
  • Involvement in diseaseDefects in TGFBI are the cause of epithelial basement membrane corneal dystrophy (EBMD) [MIM:121820]; also known as Cogan corneal dystrophy or map-dot-fingerprint type corneal dystrophy. EBMD is a bilateral anterior corneal dystrophy characterized by grayish epithelial fingerprint lines, geographic map-like lines, and dots (or microcysts) on slit-lamp examination. Pathologic studies show abnormal, redundant basement membrane and intraepithelial lacunae filled with cellular debris. Although this disorder usually is not considered to be inherited, families with autosomal dominant inheritance have been identified.
    Defects in TGFBI are the cause of corneal dystrophy Groenouw type 1 (CDGG1) [MIM:121900]; also known as corneal dystrophy granular type. Inheritance is autosomal dominant. Corneal dystrophies show progressive opacification of the cornea leading to severe visual handicap.
    Defects in TGFBI are the cause of corneal dystrophy lattice type 1 (CDL1) [MIM:122200]. Inheritance is autosomal dominant.
    Defects in TGFBI are a cause of corneal dystrophy Thiel-Behnke type (CDTB) [MIM:602082]; also known as corneal dystrophy of Bowman layer type 2 (CDB2).
    Defects in TGFBI are the cause of Reis-Buecklers corneal dystrophy (CDRB) [MIM:608470]; also known as corneal dystrophy of Bowman layer type 1 (CDB1).
    Defects in TGFBI are the cause of lattice corneal dystrophy type 3A (CDL3A) [MIM:608471]. CDL3A clinically resembles to lattice corneal dystrophy type 3, but differs in that its age of onset is 70 to 90 years. It has an autosomal dominant inheritance pattern.
    Defects in TGFBI are the cause of Avellino corneal dystrophy (ACD) [MIM:607541]. ACD could be considered a variant of granular dystrophy with a significant amyloidogenic tendency. Inheritance is autosomal dominant.
  • Sequence similaritiesContains 1 EMI domain.
    Contains 4 FAS1 domains.
  • Post-translational
    modifications    Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • Cellular localizationSecreted > extracellular space > extracellular matrix. May be associated both with microfibrils and with the cell surface.

    • Target information above from: UniProt accession Q15582 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    TGFBI protein (Human) images

    • SDS-PAGE - TGFBI protein (Human) (ab86989)
      SDS-PAGE - TGFBI protein (Human) (ab86989)
      15% SDS-PAGE showing ab86989 at approximately 19.9kDa (3µg).
      Note: Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.

    References for TGFBI protein (Human) (ab86989)

    ab86989 has not yet been referenced specifically in any publications.

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