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Overview

  • Product nameTIMP1 protein (His tag)See all TIMP1 proteins and peptides ...
  • Protein descriptionRecombinant full length protein (Human), contains an N-terminal hexahistidine tag. An 184 amino acid fragment (24-207) corresponding to the mature TIMP1 protein.
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab55236 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE
  • Application notesSDS-PAGE: Use at an assay dependent dilution. Runs as a band of ~24kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        ClgiCollagenase inhibitorEPA
        EPOErythroid Potentiating ActivityErythroid-potentiating activityFibroblast collagenase inhibitorFLJ90373HCIHuman Collagenase InhibitorMetalloproteinase inhibitor 1Metalloproteinase inhibitor 1 precursorOTTHUMP00000023214TIMPTIMP 1TIMP metallopeptidase inhibitor 1TIMP-1Timp1TIMP1 proteinTIMP1_HUMANTissue Inhibitor of Metalloproteinase 1Tissue inhibitor of metalloproteinasesTissue inhibitor of metalloproteinases 1Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor
      see all
  • FunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
  • Sequence similaritiesBelongs to the protease inhibitor I35 (TIMP) family.
    Contains 1 NTR domain.
  • Post-translational
    modifications    The activity of TIMP1 is dependent on the presence of disulfide bonds.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P01033 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    TIMP1 protein (His tag) images

    • SDS-PAGE - TIMP1 protein (His tag) (ab55236)
      SDS-PAGE - TIMP1 protein (His tag) (ab55236)
      ab55236 on SDS-PAGE

    References for TIMP1 protein (His tag) (ab55236)

    ab55236 has not yet been referenced specifically in any publications.

    Publishing research using ab55236 ? Please let us know so that we can cite the reference in this datasheet

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