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Overview

  • Product nameTIMP1 protein (Human)See all TIMP1 proteins and peptides ...
  • Protein descriptionFull length Human TIMP1 protein (purified from stimulated human fibroblasts).
  • Expression hostNative

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesTIMP1 is purified from stimulated human fibroblasts, and is essentially free of contaminating MMPs or other known TIMPs.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, PBS, pH 7.4
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab39313 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution. Produces a band of approximately 29 kDa due to glycosylation.

    Protein info

    • Alternative names
        ClgiCollagenase inhibitorEPA
        EPOErythroid Potentiating ActivityErythroid-potentiating activityFibroblast collagenase inhibitorFLJ90373HCIHuman Collagenase InhibitorMetalloproteinase inhibitor 1Metalloproteinase inhibitor 1 precursorOTTHUMP00000023214TIMPTIMP 1TIMP metallopeptidase inhibitor 1TIMP-1Timp1TIMP1 proteinTIMP1_HUMANTissue Inhibitor of Metalloproteinase 1Tissue inhibitor of metalloproteinasesTissue inhibitor of metalloproteinases 1Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor
      see all
  • FunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
  • Sequence similaritiesBelongs to the protease inhibitor I35 (TIMP) family.
    Contains 1 NTR domain.
  • Post-translational
    modifications    The activity of TIMP1 is dependent on the presence of disulfide bonds.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P01033 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for TIMP1 protein (Human) (ab39313)

    ab39313 has not yet been referenced specifically in any publications.

    Publishing research using ab39313 ? Please let us know so that we can cite the reference in this datasheet

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