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Anti-TIMP2 antibody - Loop 1 (ab38973)

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This product is covered by the Abpromise guarantee. Our scientific support team are available to answer any questions or queries - fill out an inquiry form for ab38973 for help.

Alternatively, you can search the previous enquiries about this product to see if your query has already been answered.

2 questions for ab38973

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Question 1

Friday 23-December-2011

Thanks for your kindly reply, after contacting with this customer and passed this information to him, he also wants to know the immunogen sequence of this antibody; could you please help this customer to solve the problem? Thanks for your kindly help

ANSWER:

  

Thank you for your reply.

This information is commercially sensitive. As Kate confirmed, the epitope of ab38973 is located in the largest loop of TIMP-2, loop #1. This is an internal epitope, in the first 1/3 of the protein, from the amino end. Here is the full length human TIMP-2 protein sequence (P16035):

MGAAARTLRL ALGLLLLATL LRPADACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND IYGNPIKRIQ YEIKQIKMFK GPEKDIEFIY TAPSSAVCGV SLDVGGKKEY LIAGKAEGDG KMHITLCDFI VPWDTLSTTQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE KNINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP

Just let me know if I can be of further help.

Question 2

Thursday 22-December-2011

Dear technical support:

This customer raised an enquire about ab38973 (Anti-TIMP2 antibody - Loop 1), he wants to know whether “loop1” is means the same location with “N-terminal” or not? If not, could you please offer another suitable selection (anti N-terminal of TIMP2) to this customer?

Thanks for your kindly help. Best regards

ANSWER:

  

Thank you for your enquiry.

I can confirm that the epitope of ab38973 is located in the largest loop in TIMP-2, loop #1. This is an internal epitope, in the first 1/3 of the protein, from the amino end.

I hope this will be helpful to you. If you have any further questions, please do not hesitate to contact us.

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