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Products:Cell Biology >> Apoptosis >> Extracellular Signals >> Granzymes
Overview
Product name
Anti-TIMP3 antibody
See all TIMP3 products (11) ...
Description
Rabbit polyclonal to TIMP3
Specificity
This antibody reacts with a 23 kDa protein, known as TIMP 3.
Tested applications
ICC/IF, IHC-P, IHC-Frmore details
Cross reactivity
Reacts with
Rabbit, Human, Baboon
Immunogen
Synthetic peptide from the C-terminus region of the human TIMP-3.
Positive control
Breast carcinoma
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 1% BSA
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Metalloprotease inhibitors >> TIMPs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> TIMPs
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> TIMPs
Neuroscience >> Sensory System >> Visual system
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP Inhibitors
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> TIMP
Cell Biology >> Apoptosis >> Extracellular Signals >> Granzymes
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2169 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF
IHC-P
IHC-Fr
Four stars (1 Abreview)
Application notes
ICC/IF: Use at an assay dependent dilution (PMID 19324423).
IHC-P: Use at an assay dependent concentration.
IHC-Fr: Use at an assay dependent concentration.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Involvement in disease
Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
Sequence similarities
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.
Cellular localization
Secreted > extracellular space > extracellular matrix.
Target information above from: UniProt accessionP35625
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- HSMRK222 antibody
- K222 antibody
- K222TA2 antibody
see all
Database links
- Entrez Gene: 7078 Human
- Omim: 188826 Human
- SwissProt: P35625 Human
- Unigene: 644633 Human
- Unigene: 714168 Human
References for Anti-TIMP3 antibody (ab2169)
This product has been referenced in:
- Hurst LAet al. Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment. J Neuroimmunol 210:108-12 (2009). ICC/IF; Human.Read more (PubMed: 19324423) »
See 1 publication for this product
Publishing research using ab2169? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"