Overview

  • Product name
    Anti-TIMP4 antibody [9:4-7]
    See all TIMP4 primary antibodies
  • Description
    Mouse monoclonal [9:4-7] to TIMP4
  • Host species
    Mouse
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Full length protein corresponding to Human TIMP4.
    Database link: Q99727

  • Positive control
    • Human breast carcinoma, kidney and small intestine tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab219065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
  • Tissue specificity
    Abundant in heart and present at low levels in many other tissues.
  • Sequence similarities
    Belongs to the protease inhibitor I35 (TIMP) family.
    Contains 1 NTR domain.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Metalloproteinase inhibitor 4 antibody
    • TIMP 4 antibody
    • TIMP metallopeptidase inhibitor 4 antibody
    • TIMP-4 antibody
    • Timp4 antibody
    • TIMP4_HUMAN antibody
    • Tissue inhibitor of metalloproteinase 4 antibody
    • Tissue inhibitor of metalloproteinases 4 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human kidney tissue labeling TIMP4 with ab219065 at 10 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human small intestine tissue labeling TIMP4 with ab219065 at 10 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human breast carcinoma tissue labeling TIMP4 with ab219065 at 10 µg/ml (2) compared to isotype control at 10 µg/ml (1). Primary antibody incubation was followed by peroxidase mouse secondary antibody at 1/10000.

References

ab219065 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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