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- Secondary antibodies
- Lysates
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Product name
Anti-TLR1 antibody
See all TLR1 products (7) ...
Description
Rabbit polyclonal to TLR1
Specificity
ab37068 recognises Toll-like receptor 1 (TLR1).
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide of 16 amino acids near the amino terminus (Human)
Positive control
Mouse spleen lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Purification notes
Purified by ion exchange chromatography
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Signal Transduction >> Adapters >> Transmembrane
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab37068 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 90 kDa.
IHC-P: Use a concentration of 10 µg/ml.
Target
Function
Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Tissue specificity
Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
Sequence similarities
Belongs to the Toll-like receptor family.
Contains 12 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 TIR domain.
Cellular localization
Cell membrane. Cytoplasmic vesicle > phagosome membrane.
Target information above from: UniProt accessionQ15399
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD281 antibody
- CD281 antigen antibody
- KIAA0012 antibody
see all
Database links
- Entrez Gene: 7096 Human
- Entrez Gene: 21897 Mouse
- Omim: 601194 Human
- SwissProt: Q15399 Human
- SwissProt: Q9EPQ1 Mouse
- Unigene: 621817 Human
- Unigene: 654532 Human
- Unigene: 273024 Mouse
Anti-TLR1 antibody images:
Western blot - TLR1 antibody (ab37068)
Lane 1 : Anti-TLR1 antibody (ab37068) at 1 µg/ml
Lane 2 : Anti-TLR1 antibody (ab37068) at 2 µg/ml
Lane 3 : Anti-TLR1 antibody (ab37068) at 4 µg/ml
Lane 1 : Mouse spleen lysate
Lane 2 : Mouse spleen lysate
Lane 3 : Mouse spleen lysate
Lysates/proteins at 15 µg per lane.
Predicted band size : 90 kDa
Additional bands at : 75 kDa. We are unsure as to the identity of these extra bands.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TLR1 antibody (ab37068)
ab37068 at 10µg/ml staining TLR1 in mouse spleen tissue by IHC
References for Anti-TLR1 antibody (ab37068)
This product has been referenced in:
- Hinojosa E et al. Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J Infect Dis 200:546-54 (2009). WB; Mouse.Read more (PubMed: 19586419) »
See 1 publication for this product
Publishing research using ab37068? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"