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Product name
Anti-TLR11 antibody
See all TLR11 products (4) ...
Description
Rabbit polyclonal to TLR11
Tested applications
ICC/IF, WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Synthetic peptide corresponding to 15 amino acids near the carboxy-terminus of mouse TLR11.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purification notes
Ion exchange chromatography.
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Microbiology >> Protein >> Human Protein >> Defensin
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab21274 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: Use a concentration of 2 µg/ml.
WB: Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 90 kDa.Can be blocked with TLR11 peptide (ab39867).
IHC-P: Use at an assay dependent dilution.
Target
Relevance
Toll like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.
Cellular localization
Type I membrane protein
Alternative names
- hgnc31753 antibody
- Toll like receptor 11 antibody
Database links
- Entrez Gene: 239081 Mouse
- SwissProt: Q6R5P0 Mouse
- Unigene: 291512 Mouse
Anti-TLR11 antibody images:
Western blot - TLR11 antibody (ab21274)
Western blot analysis of TLR11 in RAW264.7 cell lysates with anti-TLR11 at (A) 0.5 and (B) 1 µg/ml.
Immunocytochemistry/ Immunofluorescence - TLR11 antibody (ab21274)
ab21274 at 2µg/ml staining TLR11 in RAW264.7 cells by ICC/IF
References for Anti-TLR11 antibody (ab21274)
ab21274 has not yet been referenced specifically in any publications.
Publishing research using ab21274? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"