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Product name
Anti-TLR2 antibody [TL2.3] (Biotin)
See all TLR2 products (32) ...
Description
Mouse monoclonal [TL2.3] to TLR2 (Biotin)
Conjugation
Biotin
Tested applications
WB, Flow Cytmore details
Cross reactivity
Reacts with
Human
Immunogen
CHO cells stably transfected with human TLR2
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Concentration
Concentration information loading...
Purity
IgG fraction
Primary antibody notes
Ab9103 is a TLR2 function blocking antibody that is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human pheriperal blood mononuclear cells.
Clonality
Monoclonal
Clone number
TL2.3
Isotype
IgG2a
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Inflammatory mediators
Signal Transduction >> Adapters >> Transmembrane
Microbiology >> Protein >> Human Protein >> Defensin
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab9103 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Flow Cyt
Application notes
Flow Cyt: Use at an assay dependent dilution.
This antibody blocks TLR2 agonist-induced cellular activation.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Tissue specificity
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Sequence similarities
Belongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
Post-translational
modifications
Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
Cellular localization
Membrane.
Target information above from: UniProt accessionO60603
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD282 antibody
- CD282 antigen antibody
- TIL 4 antibody
see all
Database links
- Entrez Gene: 7097 Human
- Omim: 603028 Human
- SwissProt: O60603 Human
- Unigene: 519033 Human
References for Anti-TLR2 antibody [TL2.3] (Biotin) (ab9103)
This product has been referenced in:
- Flo TH et al. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 69:474-81 (2001).Read more (PubMed: 11261796) »
See 1 publication for this product
Publishing research using ab9103? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"