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Anti-TLR2 antibody [TL2.3] (ab9102)

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Overview

Product name

Anti-TLR2 antibody [TL2.3]
See all TLR2 products (32) ...

Description

Mouse monoclonal [TL2.3] to TLR2

Tested applications

IHC-Fr, ICC/IF, WB, Flow Cytmore details

Cross reactivity

Reacts with

Human

Immunogen

CHO cells stably transfected with human TLR2

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

PBS with 0.1% BSA 0.02% sodium azide pH7.2

Concentration

Concentration information loading...

Purity

IgG fraction

Primary antibody notes

Ab9102 is a TLR2 function blocking antibody that is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human pheriperal blood mononuclear cells.

Clonality

Monoclonal

Clone number

TL2.3

Isotype

IgG2a

Research areas

Immunology >> Innate Immunity >> TLR Signaling
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Inflammatory mediators
Signal Transduction >> Adapters >> Transmembrane
Microbiology >> Protein >> Human Protein >> Defensin
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.

Applications

Show applications key

Our Abpromise guarantee covers the use of ab9102 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-Fr

     

  • ICC/IF

     

  • WB

     

  • Flow Cyt

     

Application notes

Flow Cyt: Use at an assay dependent concentration.
ICC/IF: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution. Fix with acetone (see Flo et al).
WB: Use at an assay dependent dilution.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Tissue specificity

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Sequence similarities

Belongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain.

Post-translational
modifications

Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.

Cellular localization

Membrane.

Target information above from: UniProt accessionO60603 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CD282 antibody
  • CD282 antigen antibody
  • TIL 4 antibody
  • TIL4 antibody
  • TLR 2 antibody
  • TLR2 antibody
  • TLR2_HUMAN antibody
  • Toll like receptor 2 antibody
  • Toll like receptor 2 precursor antibody
  • Toll-like receptor 2 antibody
  • Toll/interleukin 1 receptor like 4 antibody
  • Toll/interleukin 1 receptor like protein 4 antibody
  • Toll/interleukin receptor like protein 4 antibody
  • Toll/interleukin-1 receptor-like protein 4 antibody
see all

Database links

References for Anti-TLR2 antibody [TL2.3] (ab9102)

This product has been referenced in:

  • Westerholm-Ormio M  et al. Infiltration of Foxp3- and Toll-like receptor-4-positive cells in the intestines of children with food allergy. J Pediatr Gastroenterol Nutr 50:367-76 (2010). IHC-Fr; Human.Read more (PubMed: 20216098) »
  • Flo TH  et al. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 69:474-81 (2001).Read more (PubMed: 11261796) »

See all 2 publications for this product

Publishing research using ab9102? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"