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- Secondary antibodies
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Product name
Anti-TLR6 antibody
See all TLR6 products (9) ...
Description
Rabbit polyclonal to TLR6
Specificity
TLR6 antibody is specific to TLR6. It does not recognize TLR1.
Tested applications
WB, ICC/IFmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide corresponding to 15 amino acids near the amino terminus of the human TLR6 protein.
Positive control
Jurkat cell lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
This antibody was purified by affinity chromatography.
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Innate and adaptive immunity
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> NFkB pathway
Signal Transduction >> Adapters >> Transmembrane
Microbiology >> Protein >> Human Protein >> Defensin
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab37072 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 92 kDa).
ICC/IF: Use a concentration of 10 µg/ml.
Target
Function
Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.
Tissue specificity
Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Sequence similarities
Belongs to the Toll-like receptor family.
Contains 12 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 TIR domain.
Cellular localization
Cell membrane. Cytoplasmic vesicle > phagosome membrane.
Target information above from: UniProt accessionQ9Y2C9
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD286 antibody
- CD286 antigen antibody
- TLR 6 antibody
see all
Database links
- Entrez Gene: 10333 Human
- Entrez Gene: 21899 Mouse
- Omim: 605403 Human
- SwissProt: Q9Y2C9 Human
- SwissProt: Q9EPW9 Mouse
- Unigene: 662185 Human
- Unigene: 575090 Human
- Unigene: 42146 Mouse
Anti-TLR6 antibody images:
Western blot - TLR6 antibody (ab37072)
Lane 1 : Anti-TLR6 antibody (ab37072) at 0.5 µg/ml
Lane 2 : Anti-TLR6 antibody (ab37072) at 1 µg/ml
Lane 3 : Anti-TLR6 antibody (ab37072) at 2 µg/ml
Lane 1 : Jurkat cell lysate
Lane 2 : Jurkat cell lysate
Lane 3 : Jurkat cell lysate
Lysates/proteins at 15 µg per lane.
Secondary
goat anti-rabbit HRP at 1/10000 dilution
Predicted band size : 92 kDa
Observed band size : 100 kDa (why is the actual band size different from the predicted?)
Additional bands at : 55 kDa,80 kDa. We are unsure as to the identity of these extra bands.
Immunocytochemistry/ Immunofluorescence - TLR6 antibody (ab37072)
ab37072 at 10 µg/ml staining TLR6 in Jurkat cells by ICC/IF
References for Anti-TLR6 antibody (ab37072)
ab37072 has not yet been referenced specifically in any publications.
Publishing research using ab37072? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"