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Anti-TLR9 antibody [26C593] (ab12121)

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Overview

Product name

Anti-TLR9 antibody [26C593]
See all TLR9 products (15) ...

Description

Mouse monoclonal [26C593] to TLR9

Specificity

This antibody is specific for TLR9.

Tested applications

IP, IHC-Fr, IHC-P, ICC, Flow Cyt, WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human, Rhesus monkey

Immunogen

Synthetic peptide conjugated to KLH, corresponding to amino acids 268-284 of TLR9.

Positive control

Human PBMC extracts.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein G purified

Purification notes

Affinity purified.

Clonality

Monoclonal

Clone number

26C593

Isotype

IgG1

Research areas

Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Adapters >> Transmembrane
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.

  • Western blot - TLR9 antibody [26C593] (ab12121)Western blot - TLR9 antibody [26C593] (ab12121) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab12121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Tissue specificity

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Sequence similarities

Belongs to the Toll-like receptor family.
Contains 26 LRR (leucine-rich) repeats.
Contains 1 TIR domain.

Cellular localization

Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

Target information above from: UniProt accessionQ9NR96 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CD 289 antibody
  • CD289 antibody
  • TLR 9 antibody
  • TLR9 antibody
  • TLR9_HUMAN antibody
  • Toll like receptor 9 antibody
  • Toll like receptor 9 isoform A precursor antibody
  • Toll like receptor 9 isoform B antibody
  • Toll-like receptor 9 antibody
see all

Database links

see all

Anti-TLR9 antibody [26C593] images:

  Western blot - TLR9 antibody [26C593] (ab12121)

Western blot - TLR9 antibody [26C593] (ab12121)



Predicted band size : 117 kDa


TLR9 detection by Western blot. The analysis of extracts from human PBMC by using ab12121 at a dilution of 2 µg/ml.

References for Anti-TLR9 antibody [26C593] (ab12121)

This product has been referenced in:

  • Liang Qet al. Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties. J Biol Chem 286:26470-9 (2011). WB, IP.Read more (PubMed: 21665946) »
  • Wang Ket al. Correlation of TLR1-10 expression in peripheral blood mononuclear cells with chronic hepatitis B and chronic hepatitis B-related liver failure. Hum Immunol 71:950-6 (2010). WB; Human.Read more (PubMed: 20667457) »

See all 4 publications for this product

Publishing research using ab12121? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"