TLR9 antibody [26C593] (ab12121)

Product Name 

TLR9 antibody [26C593]

Product type 

Primary antibodies

Description 

Mouse monoclonal [26C593] to TLR9

Immunogen 

Synthetic peptide conjugated to KLH, corresponding to amino acids 268-284 of TLR9.

Reacts with 
(species key)

Hu, Ms, Rat, RMk

Specificity 

This antibody is specific for TLR9.

Tested applications 
(see key)

Flow Cyt, ICC, IHC-Fr, IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
Flow Cyt: Use at an assay dependent dilution.
ICC: Use at an assay dependent dilution.
IHC-P: Use at an assay dependent dilution.
IHC-Fr: Use at a concentration of 10 - 20 µg/ml.
WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 120 kDa (predicted molecular weight: 117 kDa). For optimal results, primary antibody incubations should be performed at room temperature.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Human PBMC extracts.

Cellular localization 

Cell Membrane, Type I membrane protein.

Research areas 

Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Adapters >> Transmembrane
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.

Relevance 

TLR9 is a member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The gene encoding this protein is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

26C593

Isotype 

IgG1

Purity 

Protein G purified

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Affinity purified.

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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