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Anti-TLR9 antibody (ab13928)

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Overview

Product name

Anti-TLR9 antibody
See all TLR9 products (15) ...

Description

Rabbit polyclonal to TLR9

Tested applications

WB, Flow Cytmore details

Cross reactivity

Reacts with

Mouse

Does not react with

Rat, Human

Immunogen

Synthetic peptide: TPGALLGLSN LTHLSLKYNN LTKVPRQLPP SLEYLLVSYNL IVKLGPEDLA NLTSLRVLDVG GNCRRCDHAPN PCIECGQKSLH LHPETFHHLSH LEGLVLKDSSL HTLN conjugated to KLH, corresponding to amino acids 200-300 of Mouse TLR9.

TPGALLGLSN LTHLSLKYNN LTKVPRQLPP SLEYLLV SYNL IVKLGPEDLA NLTSLRVLDV G GNCRRCDHAP N PCIECGQKSL H LHPETFHHLS H LEGLVLKDSS L HTLN

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

Whole cell lysate from mouse intestinal tissue lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Adapters >> Transmembrane
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.

  • Western blot - TLR9 antibody (ab13928)Western blot - TLR9 antibody (ab13928) image (enlarge)

  • Flow Cytometry - TLR9 antibody (ab13928)Flow Cytometry - TLR9 antibody (ab13928) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab13928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Tissue specificity

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Sequence similarities

Belongs to the Toll-like receptor family.
Contains 26 LRR (leucine-rich) repeats.
Contains 1 TIR domain.

Cellular localization

Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.

Target information above from: UniProt accessionQ9NR96 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CD 289 antibody
  • CD289 antibody
  • TLR 9 antibody
  • TLR9 antibody
  • TLR9_HUMAN antibody
  • Toll like receptor 9 antibody
  • Toll like receptor 9 isoform A precursor antibody
  • Toll like receptor 9 isoform B antibody
  • Toll-like receptor 9 antibody
see all

Database links

Anti-TLR9 antibody images:

  Western blot - TLR9 antibody (ab13928)

Western blot - TLR9 antibody (ab13928)

ab13928, at a 0.5 ug/ml concentration, staining approximately 113 kDa mouse TLR9 in whole cell lysate by Western blot.

  Flow Cytometry - TLR9 antibody (ab13928)

Flow Cytometry - TLR9 antibody (ab13928)

flow cytometric analysis of ab13928 TLR9 in Raw cells at 2ug for 10^6 cells.

References for Anti-TLR9 antibody (ab13928)

This product has been referenced in:

  • Nakahira Ket al. Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med 203:2377-89 (2006).Read more (PubMed: 17000866) »
  • Uchijima Met al. IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA. Immunol Cell Biol 83:92-5 (2005).Read more (PubMed: 15661046) »

See all 3 publications for this product

Publishing research using ab13928? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"